3 research outputs found
Sign patterns for chemical reaction networks
Most differential equations found in chemical reaction networks (CRNs) have
the form , where lies in the nonnegative orthant, where
is a real matrix (the stoichiometric matrix) and is a column vector
consisting of real-valued functions having a special relationship to . Our
main interest will be in the Jacobian matrix, , of , in particular
in whether or not each entry has the same sign for all in the
orthant, i.e., the Jacobian respects a sign pattern. In other words species
always acts on species in an inhibitory way or its action is always
excitatory.
In Helton, Klep, Gomez we gave necessary and sufficient conditions on the
species-reaction graph naturally associated to which guarantee that the
Jacobian of the associated CRN has a sign pattern. In this paper, given we
give a construction which adds certain rows and columns to , thereby
producing a stoichiometric matrix corresponding to a new CRN with
some added species and reactions. The Jacobian for this CRN based on
has a sign pattern. The equilibria for the and the based CRN are
in exact one to one correspondence with each equilibrium for the original
CRN gotten from an equilibrium for the new CRN by removing its added
species. In our construction of a new CRN we are allowed to choose rate
constants for the added reactions and if we choose them large enough the
equilibrium is locally asymptotically stable if and only if the
equilibrium is locally asymptotically stable. Further properties of the
construction are shown, such as those pertaining to conserved quantities and to
how the deficiencies of the two CRNs compare.Comment: 23 page